Molecular mechanics and DNA replication regulation
نویسندگان
چکیده
منابع مشابه
The Regulation of DNA Replication and Transcription
With unwarranted enthusiasm, the popular press has embraced hypoglycemia as an explanation for a host of physical ailments. Although this has permitted purveyors of numerous "treatments" to do a brisk business, very little helpful and accurate information has been communicated about hypoglycemia. Lynn Bennion, a Stanford-based clinician, has written a book that provides the general public acces...
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Posttranslational modification of proteins by means of attachment of a small globular protein ubiquitin (i.e., ubiquitylation) represents one of the most abundant and versatile mechanisms of protein regulation employed by eukaryotic cells. Ubiquitylation influences almost every cellular process and its key role in coordination of the DNA damage response is well established. In this review we fo...
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Miniature chromosome maintenance (MCM) proteins were initially identified from autonomously replicating sequence in Saccharomyces cerevisiae. Mutations of some of these proteins such as MCM7 or MCM3 in yeast result in loss of the large chunk of yeast chromosomes. MCM7 cDNA encodes a 543-amino acid protein and is ubiquitously expressed in all tissues. Initiation of DNA replication is a complex p...
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As development unfolds, DNA replication is not only coordinated with cell proliferation, but is regulated uniquely in specific cell types and organs. This differential regulation of DNA synthesis requires crosstalk between DNA replication and differentiation. This dynamic aspect of DNA replication is highlighted by the finding that the distribution of replication origins varies between differen...
متن کاملRegulation of DNA Replication Origin Licensing
DNA replication is a fundamental biological process that serves to create two copies of the genetic material during each cell division. Complete and precise replication enables identical sets of genes to be faithfully delivered to daughter cells during each cell division. To achieve rapid duplication of the entire genome, eukaryotic cells initiate DNA replication at multiple locations on each c...
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ژورنال
عنوان ژورنال: HFSP Journal
سال: 2007
ISSN: 1955-2068
DOI: 10.2976/1.2812798